Developmental toxicity assay using high content screening of zebrafish embryos
نویسندگان
چکیده
منابع مشابه
Developmental toxicity of nonylphenol in zebrafish (Danio rerio) embryos
Present study reports the response of zebrafish embryos exposed in vivo to graded concentrations of Nonylphenol (NP), ranging from high lethal levels to lower, more environmentally relevant levels. Embryos treated with NP showing developmental abnormalities and morphological alterations in a dose-dependent pattern. Results suggest that early exposure to NP can cause direct and delayed mortaliti...
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Genistein is a phytoestrogen found at a high level in soybeans. In vitro and in vivo studies showed that high concentrations of genistein caused toxic effects. This study was designed to test the feasibility of zebrafish embryos for evaluating developmental toxicity and estrogenic potential of high genistein concentrations. The zebrafish embryos at 24 h post-fertilization were exposed to genist...
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Surface disinfection of fertilized fish eggs is widely used in aquaculture to reduce extraovum pathogens that may be released from brood fish during spawning, and this is routinely used in zebrafish Danio rerio research laboratories. Most laboratories use approximately 25 to 50 ppm unbuffered chlorine solution for 5 to 10 min. Treatment of embryos with chlorine has significant germicidal effect...
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ژورنال
عنوان ژورنال: Journal of Applied Toxicology
سال: 2014
ISSN: 0260-437X
DOI: 10.1002/jat.3029